Variant position: 279 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 295 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GLIYVLVIEIHHPEPDSVFK TEQSEDKPEKYELSVIM
Mouse GLIYVLFIQMHHSNPDPEVK AEPAENNLEKHELSVIM
Rat GLIYILFIQMHHSKLDPDMK AEPSENNLEKHELSVIM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 295 Aquaporin-9
267 – 295 Cytoplasmic
Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol.
Ishibashi K.; Kuwahara M.; Gu Y.; Tanaka Y.; Marumo F.; Sasaki S.;
Biochem. Biophys. Res. Commun. 244:268-274(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; VARIANT ALA-279;
Functional and molecular characterization of the human neutral solute channel aquaporin-9.
Tsukaguchi H.; Weremowicz S.; Morton C.C.; Hediger M.A.;
Am. J. Physiol. 277:F685-F696(1999)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; FUNCTION; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; VARIANT ALA-279;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT ALA-279;
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