Variant position: 840 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1127 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human T--NLHLESELDALASLENHVK IEP--ADMNESCKQSGLSSLVNG
Mouse T--NLHLESELDTLTGLENHVK TEP--TDISESCKQSGLSN
Xenopus laevis T--NVHLETDLESLAALENNVK TEP--NNTSQSCRQSSHVS
Zebrafish ILGSVSTGSVQDILRTLGENVK SEPQSDNLSSCTNPNSRAT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1127 E3 ubiquitin-protein ligase TRIM33
TIF1gamma, a novel member of the transcriptional intermediary factor 1 family.
Venturini L.; You J.; Stadler M.; Galien R.; Lallemand V.; Koken M.H.M.; Mattei M.-G.; Ganser A.; Chambon P.; Losson R.; De The H.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA); FUNCTION; SUBUNIT; VARIANT THR-840;
The tripartite motif family identifies cell compartments.
Reymond A.; Meroni G.; Fantozzi A.; Merla G.; Cairo S.; Luzi L.; Riganelli D.; Zanaria E.; Messali S.; Cainarca S.; Guffanti A.; Minucci S.; Pelicci P.G.; Ballabio A.;
EMBO J. 20:2140-2151(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA); VARIANT THR-840;
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Kikuno R.; Nagase T.; Ishikawa K.; Hirosawa M.; Miyajima N.; Tanaka A.; Kotani H.; Nomura N.; Ohara O.;
DNA Res. 6:197-205(1999)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA); VARIANT THR-840;
The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas.
Klugbauer S.; Rabes H.M.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 76-1127 (ISOFORMS ALPHA AND BETA); CHROMOSOMAL TRANSLOCATION WITH RET; VARIANT THR-840;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.