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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P11509: Variant p.Val365Met

Cytochrome P450 2A6
Gene: CYP2A6
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Variant information Variant position: help 365 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Valine (V) to Methionine (M) at position 365 (V365M, p.Val365Met). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic. The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In allele CYP2A6*17; increases phenacetin O-deethylation activity 2 fold. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 365 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 494 The length of the canonical sequence.
Location on the sequence: help DRAKMPYMEAVIHEIQRFGD V IPMSLARRVKKDTKFRDFFL The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 494 Cytochrome P450 2A6
Mutagenesis 369 – 369 S -> G. Increases phenacetin O-deethylation activity 3 fold. Increases phenacetin O-deethylation activity 38 fold; when associated with S-208; F-300 and A-301.
Mutagenesis 372 – 372 R -> H. Increases phenacetin O-deethylation activity 2 fold.



Literature citations
Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes.
DeVore N.M.; Smith B.D.; Urban M.J.; Scott E.E.;
Drug Metab. Dispos. 36:2582-2590(2008)
Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 29-494 IN COMPLEX WITH PHENACETIN AND HEME; FUNCTION; CHARACTERIZATION OF VARIANTS LEU-110 AND MET-365; MUTAGENESIS OF ILE-208; SER-213; ILE-300; GLY-301; SER-369 AND ARG-372; Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
Solus J.F.; Arietta B.J.; Harris J.R.; Sexton D.P.; Steward J.Q.; McMunn C.; Ihrie P.; Mehall J.M.; Edwards T.L.; Dawson E.P.;
Pharmacogenomics 5:895-931(2004)
Cited for: VARIANTS ARG-5; ASN-29; LEU-118; GLN-128; PRO-224; MET-365; ASP-418; ASP-419; THR-471; ARG-476 AND LEU-485; A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent.
Ho M.K.; Mwenifumbo J.C.; Zhao B.; Gillam E.M.; Tyndale R.F.;
Pharmacogenet. Genomics 18:67-75(2008)
Cited for: VARIANTS CYS-203; SER-203 AND MET-365; CHARACTERIZATION OF VARIANT CYS-203;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.