Variant position: 457 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 493 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human CAGEGLARMELFLLLCAILQ HFNLKPLVDPKDIDLSPIHIG
Rhesus macaque CAGEGLARMELFLLLSAILQ HFNLKPLVDPKDIDISPVNIG
Mouse CVGEGLARMELFLLLSAILQ HFNLKSLVDPKDIDLSPVTIG
Rat CVGEGLARMELFLLLSAILQ HFNLKSLVDPKDIDLSPVTVG
Pig CVGEGLARMELFLFMAAILQ HFNLKSLVDPKDIDLSPIAIG
Bovine CVGEGLARMELFLLLAAILQ HFNLKSLVDPKDIDLSPIAIG
Rabbit CVGEGLARMELFLLLSAILQ HFNLKPLVDPEDIDLRNITVG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ASP-219; CYS-366 AND LEU-457;
Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
Solus J.F.; Arietta B.J.; Harris J.R.; Sexton D.P.; Steward J.Q.; McMunn C.; Ihrie P.; Mehall J.M.; Edwards T.L.; Dawson E.P.;
Cited for: VARIANTS ILE-179 AND LEU-457;
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