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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q96RS0: Variant p.Ile16Thr

Trimethylguanosine synthase
Gene: TGS1
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Variant information Variant position: help 16
Type of variant: help LB/B
Residue change: help From Isoleucine (I) to Threonine (T) at position 16 (I16T, p.Ile16Thr).
Physico-chemical properties: help Change from medium size and hydrophobic (I) to medium size and polar (T)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 16
Protein sequence length: help 853
Location on the sequence: help MCCEKWSRVAEMFLF I EEREDCKILCLCSRAFVEDR
Residue conservation: help 
Human                         MCCEKWSRVAEMFLFIEER-EDCKILCLCSRAFVEDR

Mouse                         MCCEKWNHVAEMLLFIEDREEEYKILCLCSRAFVED

Rat                           MCCEKWSHVAEMLLFIEDREEEYKILCLCSRAFVED

Baker's yeast                 ----------------------------MGRTFIHA

Fission yeast                 ------------------------------------
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 853 Trimethylguanosine synthase



Literature citations
Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function.
Zhu Y.-J.; Qi C.; Cao W.-Q.; Yeldandi A.V.; Rao M.S.; Reddy J.K.;
Proc. Natl. Acad. Sci. U.S.A. 98:10380-10385(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; INTERACTION WITH NCOA6; TISSUE SPECIFICITY; VARIANT THR-16; Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX.
Krackhardt A.M.; Witzens M.; Harig S.; Hodi F.S.; Zauls A.J.; Chessia M.; Barrett P.; Gribben J.G.;
Blood 100:2123-2131(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT THR-16; Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.
Wang Y.; Han K.-J.; Pang X.-W.; Vaughan H.A.; Qu W.; Dong X.-Y.; Peng J.-R.; Zhao H.-T.; Rui J.-A.; Leng X.-S.; Cebon J.; Burgess A.W.; Chen W.-F.;
J. Immunol. 169:1102-1109(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT THR-16;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.