Variant position: 754 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 853 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VYGI-ADKIEFICGDFLLLAS FLK-----ADVVFLSPPWGGPDYATA
Mouse VYGI-ADKIEFICGDFLLLAP CLK-----ADVVFLSPPWGG
Rat VYGV-ADKIEFICGDFLLLAP CLK-----ADVVFLSPPWGG
Baker's yeast SYGV-DDRIWLKRGSWKKLVS KQKLSKIKYDCVFGSPPWGG
Fission yeast IYGIPSSRVTFIQGDVLDTFK SLQFAKDYRSLVFMSPPWGG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 853 Trimethylguanosine synthase
631 – 846 Sufficient for catalytic activity
766 – 766 7-methylguanosine
763 – 763 S -> A. Decreases catalytic activity to 26 percent of wild type.
766 – 766 W -> A. Loss of catalytic activity.
752 – 754
No reference for the current variant in UniProtKB/Swiss-Prot.
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