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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot O15527: Variant p.Ser232Thr

N-glycosylase/DNA lyase
Gene: OGG1
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Variant information Variant position: help 232 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help US The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Serine (S) to Threonine (T) at position 232 (S232T, p.Ser232Thr). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and polar (S) to medium size and polar (T) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help Found in a kidney cancer sample. Any additional useful information about the variant.


Sequence information Variant position: help 232 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 345 The length of the canonical sequence.
Location on the sequence: help ARAILEEQGGLAWLQQLRES S YEEAHKALCILPGVGTKVAD The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         ARAILEEQGGLA------WLQQL-RESSYEEAHKALCILPGVGTKVAD

Mouse                         AKAILEEQGGPA------WLQQL-RVAPYEEAHKALCTLPG

Rat                           AKAILEEQGGPA------WLQQL-RVASYEEAHKALCTLPG

Drosophila                    LQEI-QKKGGQN------WFISL-KSMPFEKAREELTLLPG

Baker's yeast                 ARKLVNDKAEANITSDTTYLQSICKDAQYEDVREHLMSYNG

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 345 N-glycosylase/DNA lyase
Active site 249 – 249 Schiff-base intermediate with DNA
Alternative sequence 196 – 345 Missing. In isoform 2C.
Mutagenesis 249 – 249 K -> Q. Loss of activity.



Literature citations
Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours.
Chevillard S.; Radicella J.P.; Levalois C.; Lebeau J.; Poupon M.-F.; Oudard S.; Dutrillaux B.; Boiteux S.;
Oncogene 16:3083-3086(1998)
Cited for: VARIANTS SER-85; GLN-131 AND THR-232; CHARACTERIZATION OF VARIANT GLN-131;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.