Variant position: 232 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 345 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ARAILEEQGGLA------WLQQL-RES SYEEAHKALCILPGVGTKVAD
Mouse AKAILEEQGGPA------WLQQL-RVA PYEEAHKALCTLPG
Rat AKAILEEQGGPA------WLQQL-RVA SYEEAHKALCTLPG
Drosophila LQEI-QKKGGQN------WFISL-KSM PFEKAREELTLLPG
Baker's yeast ARKLVNDKAEANITSDTTYLQSICKDA QYEDVREHLMSYNG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 345 N-glycosylase/DNA lyase
249 – 249 Schiff-base intermediate with DNA
196 – 345 Missing. In isoform 2C.
249 – 249 K -> Q. Loss of activity.
Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours.
Chevillard S.; Radicella J.P.; Levalois C.; Lebeau J.; Poupon M.-F.; Oudard S.; Dutrillaux B.; Boiteux S.;
Cited for: VARIANTS SER-85; GLN-131 AND THR-232; CHARACTERIZATION OF VARIANT GLN-131;
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