Variant position: 723 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 846 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EESDCNIKLLDSQSDQTSKL RLSHFSKKDTPL-RNKVPGLYK
Mouse EESDCNNKSLDNQGEQNSKQ HLPHFSK-KDGLRRNKVPGLC
Xenopus laevis DEHASTPESPCQFTMKASPA HQSFFPEPKGSAPKSKVPGLL
Zebrafish VTEDNSDKEKERDSVVSNSP SSSPLDRLKPAVNRTKVSGLS
Drosophila --DSCSSDQRASSTSSSSQQ RQNFLPTSKRRV------GLS
Slime mold NNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNDNNN
Baker's yeast RDDDCDDNDGKNQITQRPSL RKSLIGARSQRI---------
Fission yeast --------------GHDALN RKNHASLPSRRI-------VY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 846 Exonuclease 1
600 – 846 Interaction with MSH2
714 – 714 Phosphoserine; by ATR
714 – 714 S -> A. No rescue of HU-induced degradation and loss of HU-induced increase of phosphorylation. No rescue of HU-induced degradation; when associated with A-621. No rescue of HU-induced degradation; when associated with A-454. Loss of HU-sensitivity and resistance to HU-induced degradation; when associated with A-454 and A-621.
Human exonuclease I interacts with the mismatch repair protein hMSH2.
Schmutte C.; Marinescu R.C.; Sadoff M.M.; Guerrette S.; Overhauser J.; Fishel R.;
Cancer Res. 58:4537-4542(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); INTERACTION WITH MSH2; TISSUE SPECIFICITY; VARIANTS ARG-354; LYS-589; GLY-670; CYS-723 AND LEU-757;
Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination.
Tishkoff D.X.; Amin N.S.; Viars C.S.; Arden K.C.; Kolodner R.D.;
Cancer Res. 58:5027-5031(1998)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]; ALTERNATIVE SPLICING; TISSUE SPECIFICITY; VARIANTS ARG-354; LYS-589; GLY-670 AND CYS-723;
Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1.
Wilson D.M. III; Carney J.P.; Coleman M.A.; Adamson A.W.; Christensen M.; Lamerdin J.E.;
Nucleic Acids Res. 26:3762-3768(1998)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]; ALTERNATIVE SPLICING; FUNCTION; TISSUE SPECIFICITY; VARIANTS ARG-354; LYS-589; GLY-670 AND CYS-723;
Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance.
Qiu J.; Qian Y.; Chen V.; Guan M.-X.; Shen B.;
J. Biol. Chem. 274:17893-17900(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); PROTEIN SEQUENCE OF 1-7 (ISOFORMS 1/2); FUNCTION; VARIANTS ARG-354; LYS-589; GLY-670 AND CYS-723;
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ILE-76; GLY-93; SER-279; SER-299; ARG-354; ASN-428; MET-439; TYR-456; MET-458; LEU-460; THR-503; LYS-589; GLN-634; GLY-670; CYS-723; LEU-757 AND GLU-759;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANTS GLY-670 AND CYS-723;
The full-ORF clone resource of the German cDNA consortium.
Bechtel S.; Rosenfelder H.; Duda A.; Schmidt C.P.; Ernst U.; Wellenreuther R.; Mehrle A.; Schuster C.; Bahr A.; Bloecker H.; Heubner D.; Hoerlein A.; Michel G.; Wedler H.; Koehrer K.; Ottenwaelder B.; Poustka A.; Wiemann S.; Schupp I.;
BMC Genomics 8:399-399(2007)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 175-846 (ISOFORM 1); VARIANTS LYS-589; GLY-670 AND CYS-723;
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