Variant position: 770 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 846 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LSTTKIKPLGPARASGLSKK PASIQKRKHHNAENKPGLQIK
Mouse FSTTKIKPLVPARVSGLSKK SGSMQTRKHHDVENKPGLQTK
Xenopus laevis GLRTKVKPRAPAKVSGLTNR SNTKATR---NNENVPGLQAT
Zebrafish GKGGKIETSAPARASGLRRK PSGKKNV---NNENSPGLQAT
Drosophila GTP---KSRTNGKLGAVSQN QTKLSMF---GFQTKPVLK--
Slime mold KSFNSIVLTTTSATTSITQQ DNEIYTTPKKKLPSTPISSSS
Baker's yeast KSVDERKSFNSSPILHEESK KRDIETT--KSSQARPAVRSI
Fission yeast -------PSSPSTPISMNPR PKGILSL--------------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 846 Exonuclease 1
600 – 846 Interaction with MSH2
Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome.
Sun X.; Zheng L.; Shen B.;
Cancer Res. 62:6026-6030(2002)
Cited for: FUNCTION; INTERACTION WITH MLH1 AND MSH2; CHARACTERIZATION OF VARIANTS LYS-109; ARG-410; SER-640; GLU-759 AND LEU-770;
Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms.
Wu Y.; Berends M.J.W.; Post J.G.; Mensink R.G.J.; Verlind E.; van der Sluis T.; Kempinga C.; Sijmons R.H.; van der Zee A.G.J.; Hollema H.; Kleibeuker J.H.; Buys C.H.C.M.; Hofstra R.M.W.;
Cited for: VARIANTS ALA-27; LYS-109; ARG-410; GLY-610; ALA-640; SER-640; GLU-759 AND LEU-770;
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