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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P00519: Variant p.Thr852Pro

Tyrosine-protein kinase ABL1
Gene: ABL1
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Variant information Variant position: help 852
Type of variant: help LB/B
Residue change: help From Threonine (T) to Proline (P) at position 852 (T852P, p.Thr852Pro).
Physico-chemical properties: help Change from medium size and polar (T) to medium size and hydrophobic (P)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 852
Protein sequence length: help 1130
Location on the sequence: help HKEEAGKGSALGTPAAAEPV T PTSKAGSGAPGGTSKGPAEE
Residue conservation: help 
Human                         HKEEAGKGSA--L------GTPAAAEPVTPTSKAGSGAPGGTSKGPAEE

Mouse                         HKEEATKGSASGM------GTPATAEPAPPSNKVG------

Caenorhabditis elegans        NVEGELKAKIRNLRHVPKEESNTSSQEDLPLDATDNTNDSI
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 1130 Tyrosine-protein kinase ABL1
Region 518 – 996 Disordered
Modified residue 844 – 844 Phosphothreonine
Modified residue 852 – 852 Phosphothreonine
Modified residue 855 – 855 Phosphoserine



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS VAL-706; PRO-852; SER-900 AND LEU-972;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.