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UniProtKB/Swiss-Prot P30044: Variant p.Tyr33Cys

Peroxiredoxin-5, mitochondrial
Gene: PRDX5
Variant information

Variant position:  33
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Tyrosine (Y) to Cysteine (C) at position 33 (Y33C, p.Tyr33Cys).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and aromatic (Y) to medium size and polar (C)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -2
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  33
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  214
The length of the canonical sequence.

Location on the sequence:   AGYILVGGAGGQSAAAAARR  Y SEGEWASGGVRSFSRAAAAM
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         AGYI-----LVGGAGGQSAAAAARRYSEGEWASGGVRSFSRAAAAM

Mouse                         ASSV-----LRAS---TCLAGRAGRKEAG-WECGGARSFSS

Rat                           AGSV-----LRASATWTCVAGRAGRKGAG-WECGGARSFSS

Bovine                        PGSVVSRATIVEGASTTAAGTRGCLEGILEWTFGGVRGFRS

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Transit peptide 1 – 52 Mitochondrion
Alternative sequence 1 – 52 Missing. In isoform Cytoplasmic+peroxisomal.


Literature citations

A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase-III-driven transcription of the Alu-family retroposons in vitro.
Kropotov A.; Sedova V.; Ivanov V.; Sazeeva N.; Tomilin A.; Krutilina R.; Oei S.L.; Griesenbeck J.; Buchlow G.; Tomilin N.;
Eur. J. Biochem. 260:336-346(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MITOCHONDRIAL); VARIANT CYS-33;

Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family.
Knoops B.; Clippe A.; Bogard C.; Arsalane K.; Wattiez R.; Hermans C.; Duconseille E.; Falmagne P.; Bernard A.;
J. Biol. Chem. 274:30451-30458(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MITOCHONDRIAL); PROTEIN SEQUENCE OF 54-90; FUNCTION; TISSUE SPECIFICITY; SUBCELLULAR LOCATION; VARIANT CYS-33;

Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis.
Zhou Y.; Kok K.H.; Chun A.C.S.; Wong C.M.; Wu H.W.; Lin M.C.M.; Fung P.C.W.; Kung H.-F.; Jin D.-Y.;
Biochem. Biophys. Res. Commun. 268:921-927(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CYTOPLASMIC+PEROXISOMAL); VARIANT CYS-33;

Submission
Zhang W.; Li N.; Wan T.; Cao X.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MITOCHONDRIAL); VARIANT CYS-33;

Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).
Ebert L.; Schick M.; Neubert P.; Schatten R.; Henze S.; Korn B.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MITOCHONDRIAL); VARIANT CYS-33;

Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT CYS-33;

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS MITOCHONDRIAL; 3 AND 4); VARIANT CYS-33;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.