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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q8IUX4: Variant p.Tyr307Cys

DNA dC->dU-editing enzyme APOBEC-3F
Gene: APOBEC3F
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Variant information Variant position: help 307
Type of variant: help LB/B
Residue change: help From Tyrosine (Y) to Cysteine (C) at position 307 (Y307C, p.Tyr307Cys).
Physico-chemical properties: help Change from large size and aromatic (Y) to medium size and polar (C)
BLOSUM score: help -2
Other resources: help


Sequence information Variant position: help 307
Protein sequence length: help 373
Location on the sequence: help VAEFLARHSNVNLTIFTARL Y YFWDTDYQEGLRSLSQEGAS
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 373 DNA dC->dU-editing enzyme APOBEC-3F
Domain 174 – 321 CMP/dCMP-type deaminase 2
Alternative sequence 80 – 373 Missing. In isoform 2.
Alternative sequence 114 – 373 Missing. In isoform 3.
Mutagenesis 289 – 289 E -> K. Abolished interaction with HIV-1 Vif protein. Resistant to HIV-1 Vif and reduces Vif binding but is still efficiently incorporated into the virion.
Mutagenesis 290 – 290 F -> K. Resistant to HIV-1 Vif and reduces Vif binding but is still efficiently incorporated into the virion.
Mutagenesis 293 – 293 R -> D. Abolished interaction with HIV-1 Vif protein.
Mutagenesis 294 – 294 H -> D. Resistant to HIV-1 Vif, reduces Vif binding and abolishes incorporation into the virion.
Mutagenesis 324 – 324 E -> KA. Resistant to HIV-1 Vif and reduces Vif binding.
Mutagenesis 324 – 324 E -> R. Abolished interaction with HIV-1 Vif protein.
Turn 307 – 310



Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1); VARIANTS THR-178; ILE-231 AND CYS-307;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.