Variant position: 177 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 434 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SHAGNKLAMQEFMILPVGAA NFREAMRIGAEVYHNLKNVIK
Mouse SHAGNKLAMQEFMILPVGAS SFREAMRIGAEVYHNLKNVIK
Rat SHAGNKLAMQEFMILPVGAS SFREAMRIGAEVYHNLKNVIK
Bovine SHAGNKLAMQEFMILPVGAE NFREAMRIGAEVYHNLKNVIK
Chicken SHAGNKLAMQEFMILPVGAD TFKEAMRIGAEVYHNLKNVIK
Xenopus laevis SHAGNKLAMQEFMILPVGAD SFKEAMRIGAEVYHNLKNVIK
Slime mold SHAGNKLAMQEFMILPVGAK DFNEAYRMGSEVYHNLKNVIS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 434 Alpha-enolase
97 – 237 Required for repression of c-myc promoter activity
158 – 158 Substrate
167 – 167 Substrate
193 – 193 N6-acetyllysine
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT LYS-177;
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