Variant position: 287 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 450 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EYMAKGSLVDYLRSRGRSVL GGDCLLKFSLDVCEAMEYLEG
Mouse EYMAKGSLVDYLRSRGRSVL GGDCLLKFSLDVCEAMEYLEG
Rat EYMAKGSLVDYLRSRGRSVL GGDCLLKFSLDVCEAMEYLEG
Bovine EYMAKGSLVDYLRSRGRSVL GGDCLLKFSLDVCEAMEYLEG
Chicken EYMAKGSLVDYLRSRGRSVL GGDCLLKFSLDVCEAMEYLEA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 450 Tyrosine-protein kinase CSK
195 – 449 Protein kinase
304 – 304 Phosphotyrosine
304 – 304 Y -> F. Decreases activity by two-thirds and alters conformation.
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ASP-287; GLN-398 AND ARG-442;
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