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UniProtKB/Swiss-Prot P19174: Variant p.Ser739Thr

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Gene: PLCG1
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Variant information Variant position: help 739
Type of variant: help LB/B
Residue change: help From Serine (S) to Threonine (T) at position 739 (S739T, p.Ser739Thr).
Physico-chemical properties: help Change from small size and polar (S) to medium size and polar (T)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 739
Protein sequence length: help 1290
Location on the sequence: help QEGQTVMLGNSEFDSLVDLI S YYEKHPLYRKMKLRYPINEE
Residue conservation: help 
Human                         QEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEE

Mouse                         QEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEE

Rat                           QEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEE

Bovine                        QEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEE
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 2 – 1290 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Domain 668 – 756 SH2 2
Helix 734 – 741



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ASN-209; GLY-279; THR-739 AND THR-813;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.