Sequence information
Variant position: 32 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 291 The length of the canonical sequence.
Location on the sequence:
ALTLLVLLRGPPVARAGASS
A GLGPVVRCEPCDARALAQCA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ALTLLVLLRGPPVARAGASSA GLGPVVRCEPCDARALAQCA
Mouse ALTALTLLRGPPVARAGAGAV GAGPVVRCEPCDARALSQCA
Rat ALTALTLLRGPPVARAGAGAV GAGPVVRCEPCDARALAQCA
Pig ALIALALLRGPPAARAGSGAA GTGPVVRCEPCDARALAQCA
Bovine ALTALTLLRGPPAARAGAGTM GAGPVVRCEPCDARAVAQCA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
28 – 291
Insulin-like growth factor-binding protein 3
Region
28 – 134
IGF-binding
Literature citations
Cloning and expression of the growth hormone-dependent insulin-like growth factor-binding protein.
Wood W.I.; Cachianes G.; Henzel W.J.; Winslow G.A.; Spencer S.A.; Hellmiss R.; Martin J.L.; Baxter R.C.;
Mol. Endocrinol. 2:1176-1185(1988)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT GLY-32;
Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity.
Cubbage M.L.; Suwanichkul A.; Powell D.R.;
J. Biol. Chem. 265:12642-12649(1990)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1); VARIANT GLY-32;
Analysis of the primary structure of insulin-like growth factor binding protein-3 cDNA from Werner syndrome fibroblasts.
Thweatt R.; Fleischmann R.; Goldstein S.;
DNA Seq. 4:43-46(1993)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT GLY-32;
Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species.
Roghani M.; Segovia B.; Whitechurch O.; Binoux M.;
Growth Regul. 1:125-130(1991)
Cited for: PROTEIN SEQUENCE OF 28-45; INTERACTION WITH IGF2; VARIANT GLY-32;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.