Variant position: 230 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 488 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GDLRDIGAGKGKYYAVNFPM RDGIDDESYGQIFKPIISKVM
Mouse GDLRDIGAGKGKYYAVNFPM RDGIDDESYGQIFKPIISKVM
Chicken GDLRDIGAGKGKYYAVNFPM RDGIDDESYGQIFKPIISKVM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 488 Histone deacetylase 2
9 – 322 Histone deacetylase
221 – 221 N6-acetyllysine
Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.
Yang W.-M.; Inouye C.J.; Zeng Y.; Bearss D.; Seto E.;
Proc. Natl. Acad. Sci. U.S.A. 93:12845-12850(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT CYS-230;
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