Variant position: 138 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1548 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SVETPGCPAEFLNIRIPPGD PVFDPDQRGDVVLPFQRSRWD
Rat SVETPGCPAEFLNIYIPRGD PVFDPDKRGNVVLPFQRSRWD
Pig SIEKPGCPAEFLNIHIPPGD PVFDPHKSGDVVLPFQRSRWD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
26 – 1548 Dual oxidase 2
26 – 601 Extracellular
30 – 596 Peroxidase-like; mediates peroxidase activity
124 – 1162
Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.
Edens W.A.; Sharling L.; Cheng G.; Shapira R.; Kinkade J.M.; Lee T.; Edens H.A.; Tang X.; Sullards C.; Flaherty D.B.; Benian G.M.; Lambeth J.D.;
J. Cell Biol. 154:879-891(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS LEU-138 AND LEU-1067; DEVELOPMENTAL STAGE; TISSUE SPECIFICITY;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.