Sequence information
Variant position: 59 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
TTKTYFPHFDLSHGSAQVKG
H GKKVADALTNAVAHVDDMPN
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TTKTYFPHF-DLSHGSAQVKGH GKKVADALTNAVAHVDDMPN
Gorilla TTKTYFPHF-DLSHGSAQVKGH GKKVADALTNAVAHVDDMP
TTKTYFPHF-DLSPGSAQVKAH GKKVADALTTAVAHLDDLP
Rhesus macaque TTKTYFPHF-DLSHGSAQVKGH GKKVADALTLAVGHVDDMP
Chimpanzee TTKTYFPHF-DLSHGSAQVKGH GKKVADALTNAVAHVDDMP
Mouse TTKTYFPHF-DVSHGSAQVKGH GKKVADALASAAGHLDDLP
Rat TTKTYFSHI-DVSPGSAQVKAH GKKVADALAKAADHVEDLP
Pig TTKTYFPHF-NLSHGSDQVKAH GQKVADALTKAVGHLDDLP
Bovine TTKTYFPHF-DLSHGSAQVKGH GAKVAAALTKAVEHLDDLP
Rabbit TTKTYFPHF-DFTHGSEQIKAH GKKVSEALTKAVGHLDDLP
Sheep TTKTYFPHF-DLSHGSAQVKGH GEKVAAALTKAVGHLDDLP
Cat TTKTYFPHF-DLSHGSAQVKAH GQKVADALTQAVAHMDDLP
Horse TTKTYFPHF-DLSHGSAQVKAH GKKVGDALTLAVGHLDDLP
Chicken PTKTYFPHF-DLSHGSAQIKGH GKKVVAALIEAANHIDDIA
Xenopus tropicalis KTKTYFPDF-DFSEHSKHILAH GKKVSDALNEACNHLDNIA
Zebrafish QTKTYFSHWADLSPGSGPVKKH GKTIMGAVGEAISKIDDLV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Metal binding
59 – 59
Iron (heme b distal ligand)
Site
57 – 57
Not glycated
Site
61 – 61
Not glycated
Modified residue
41 – 41
N6-succinyllysine; alternate
Modified residue
50 – 50
Phosphoserine
Glycosylation
41 – 41
N-linked (Glc) (glycation) lysine; alternate
Glycosylation
62 – 62
N-linked (Glc) (glycation) lysine
Helix
54 – 72
Literature citations
Two new alpha chain variants: Hb Boghe [alpha58(E7)His-->Gln, alpha2], a variant on the distal histidine, and Hb Charolles [alpha103(G10)His-Tyr, alpha1].
Lacan P.; Francina A.; Souillet G.; Aubry M.; Couprie N.; Dementhon L.; Becchi M.;
Hemoglobin 23:345-352(1999)
Cited for: VARIANT BOGHE GLN-59; VARIANT CHAROLLES TYR-104;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.