Sequence information
Variant position: 95 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
DDMPNALSALSDLHAHKLRV
D PVNFKLLSHCLLVTLAAHLP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DDMPNALSALSDLHAHKLRVD PVNFKLLSHCLLVTLAAHLP
Gorilla DDMPNALSALSDLHAHKLRVD PVNFKLLSHCLLVTLAAHLP
DDLPGALSALSDLHAYKLRVD PVNFKLLSHCLLVTLACHHP
Rhesus macaque DDMPNALSALSDLHAHKLRVD PVNFKLLSHCLLVTLAAHLP
Chimpanzee DDMPNALSALSDLHAHKLRVD PVNFKLLSHCLLVTLAAHLP
Mouse DDLPGALSALSDLHAHKLRVD PVNFKLLSHCLLVTLASHHP
Rat EDLPGALSTLSDLHAHKLRVD PVNFKFLSHCLLVTLACHHP
Pig DDLPGALSALSDLHAHKLRVD PVNFKLLSHCLLVTLAAHHP
Bovine DDLPGALSELSDLHAHKLRVD PVNFKLLSHSLLVTLASHLP
Rabbit DDLPGALSTLSDLHAHKLRVD PVNFKLLSHCLLVTLANHHP
Sheep DDLPGTLSDLSDLHAHKLRVD PVNFKLLSHSLLVTLACHLP
Cat DDLPTAMSALSDLHAYKLRVD PVNFKFLSHCLLVTLACHHP
Horse DDLPGALSNLSDLHAHKLRVD PVNFKLLSHCLLSTLAVHLP
Chicken DDIAGTLSKLSDLHAHKLRVD PVNFKLLGQCFLVVVAIHHP
Xenopus tropicalis DNIAGCLSKLSDLHAYDLRVD PGNFPLLAHQILVVVAIHFP
Zebrafish DDLVGGLAALSELHAFKLRVD PANFKILSHNVIVVIAMLFP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Metal binding
88 – 88
Iron (heme b proximal ligand)
Site
91 – 91
Not glycated
Site
100 – 100
Not glycated
Modified residue
103 – 103
Phosphoserine
Modified residue
109 – 109
Phosphothreonine
Literature citations
Characterization of hemoglobin Bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity.
Abdulmalik O.; Safo M.K.; Lerner N.B.; Ochotorena J.; Daikhin E.; Lakka V.; Santacroce R.; Abraham D.J.; Asakura T.;
Am. J. Hematol. 77:268-276(2004)
Cited for: VARIANT BASSETT ALA-95; CHARACTERIZATION OF VARIANT BASSETT ALA-95;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.