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UniProtKB/Swiss-Prot P69905: Variant p.Asp95Ala

Hemoglobin subunit alpha
Gene: HBA2
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Variant information Variant position: help 95 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Aspartate (D) to Alanine (A) at position 95 (D95A, p.Asp95Ala). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and acidic (D) to small size and hydrophobic (A) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In Bassett; markedly reduced oxygen affinity. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 95 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 142 The length of the canonical sequence.
Location on the sequence: help DDMPNALSALSDLHAHKLRV D PVNFKLLSHCLLVTLAAHLP The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         DDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLP

Gorilla                       DDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLP

Rhesus macaque                DDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLP

Chimpanzee                    DDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLP

Mouse                         DDLPGALSALSDLHAHKLRVDPVNFKLLSHCLLVTLASHHP

Rat                           EDLPGALSTLSDLHAHKLRVDPVNFKFLSHCLLVTLACHHP

Pig                           DDLPGALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHHP

Bovine                        DDLPGALSELSDLHAHKLRVDPVNFKLLSHSLLVTLASHLP

Rabbit                        DDLPGALSTLSDLHAHKLRVDPVNFKLLSHCLLVTLANHHP

Sheep                         DDLPGTLSDLSDLHAHKLRVDPVNFKLLSHSLLVTLACHLP

Cat                           DDLPTAMSALSDLHAYKLRVDPVNFKFLSHCLLVTLACHHP

Horse                         DDLPGALSNLSDLHAHKLRVDPVNFKLLSHCLLSTLAVHLP

Chicken                       DDIAGTLSKLSDLHAHKLRVDPVNFKLLGQCFLVVVAIHHP

Xenopus tropicalis            DNIAGCLSKLSDLHAYDLRVDPGNFPLLAHQILVVVAIHFP

Zebrafish                     DDLVGGLAALSELHAFKLRVDPANFKILSHNVIVVIAMLFP

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Binding site 88 – 88 proximal binding residue
Site 91 – 91 Not glycated
Site 100 – 100 Not glycated
Modified residue 103 – 103 Phosphoserine
Modified residue 109 – 109 Phosphothreonine



Literature citations
Characterization of hemoglobin Bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity.
Abdulmalik O.; Safo M.K.; Lerner N.B.; Ochotorena J.; Daikhin E.; Lakka V.; Santacroce R.; Abraham D.J.; Asakura T.;
Am. J. Hematol. 77:268-276(2004)
Cited for: VARIANT BASSETT ALA-95; CHARACTERIZATION OF VARIANT BASSETT ALA-95;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.