Variant position: 418 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 977 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TLHCEAQRGSLPILYQFHHE GAALERRSANSAGGVAISFSL
Mouse --------------FQTH-- ---------------------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
16 – 977 Fc receptor-like protein 5
16 – 851 Extracellular
380 – 463 Ig-like C2-type 4
401 – 448
125 – 977 Missing. In isoform 2.
153 – 977 Missing. In isoform 5.
BXMAS1 identifies a cluster of homologous genes differentially expressed in B cells.
Nakayama Y.; Weissman S.M.; Bothwell A.L.M.;
Biochem. Biophys. Res. Commun. 285:830-837(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; VARIANTS HIS-267; ASP-418 AND ILE-466;
IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy.
Hatzivassiliou G.; Miller I.; Takizawa J.; Palanisamy N.; Rao P.H.; Iida S.; Tagawa S.; Taniwaki M.; Russo J.; Neri A.; Cattoretti G.; Clynes R.; Mendelsohn C.; Chaganti R.S.K.; Dalla-Favera R.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5); TISSUE SPECIFICITY; DISEASE; VARIANTS HIS-267; ASP-418 AND ILE-466;
Identification of a family of Fc receptor homologs with preferential B cell expression.
Davis R.S.; Wang Y.-H.; Kubagawa H.; Cooper M.D.;
Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS HIS-267; ILE-269; ASP-418 AND ILE-466;
Livingston R.J.; Shaffer T.; McFarland I.; Nguyen C.P.; Stanaway I.B.; Rajkumar N.; Johnson E.J.; da Ponte S.H.; Willa H.; Ahearn M.O.; Bertucci C.; Acklestad J.; Carroll A.; Swanson J.; Gildersleeve H.I.; Nickerson D.A.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS HIS-267; ASP-418 AND ILE-466;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANTS ILE-269; ASP-418 AND ILE-466;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.