Sequence information
Variant position: 349 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 359 The length of the canonical sequence.
Location on the sequence:
QDVRVLLGHLLMELRELSGH
R KPGTTKATAE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QDVRVLLGHLLMELRELSGHR KPGTTKATAE
Mouse QDVRALLGHLVMELRDLSVYL KPGTTKVADK
Rat QDVRILLGHLVMELRNLSAHR KPATTKS---
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
28 – 359
Fc receptor-like A
Literature citations
FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features.
Mechetina L.V.; Najakshin A.M.; Volkova O.Y.; Guselnikov S.V.; Faizulin R.Z.; Alabyev B.Y.; Chikaev N.A.; Vinogradova M.S.; Taranin A.V.;
Eur. J. Immunol. 32:87-96(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5; 6 AND 7); FUNCTION; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; VARIANT GLN-349;
An unusual Fc receptor-related protein expressed in human centroblasts.
Facchetti F.; Cella M.; Festa S.; Fremont D.H.; Colonna M.;
Proc. Natl. Acad. Sci. U.S.A. 99:3776-3781(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 9); FUNCTION; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; VARIANT GLN-349;
Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells.
Davis R.S.; Li H.; Chen C.-C.; Wang Y.-H.; Cooper M.D.; Burrows P.D.;
Int. Immunol. 14:1075-1083(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 9); TISSUE SPECIFICITY; VARIANT GLN-349;
Submission
Guselnikov S.; Najakshin A.M.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); VARIANT GLN-349;
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Clark H.F.; Gurney A.L.; Abaya E.; Baker K.; Baldwin D.T.; Brush J.; Chen J.; Chow B.; Chui C.; Crowley C.; Currell B.; Deuel B.; Dowd P.; Eaton D.; Foster J.S.; Grimaldi C.; Gu Q.; Hass P.E.; Heldens S.; Huang A.; Kim H.S.; Klimowski L.; Jin Y.; Johnson S.; Lee J.; Lewis L.; Liao D.; Mark M.R.; Robbie E.; Sanchez C.; Schoenfeld J.; Seshagiri S.; Simmons L.; Singh J.; Smith V.; Stinson J.; Vagts A.; Vandlen R.L.; Watanabe C.; Wieand D.; Woods K.; Xie M.-H.; Yansura D.G.; Yi S.; Yu G.; Yuan J.; Zhang M.; Zhang Z.; Goddard A.D.; Wood W.I.; Godowski P.J.; Gray A.M.;
Genome Res. 13:2265-2270(2003)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 9); VARIANT GLN-349;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT GLN-349;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.