Variant position: 185 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1124 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IPESSLFSPMPSEEKAASPP RPLLSN-ASATPVGRRGRLANL
Mouse VSESSYFAPVPTEDKAASPS KPPISN-ASATPVGRRGRLAN
Xenopus laevis SPSSSPPAHVPPKDIIVSPP KPQIPDVGNDTPVGRRGRFAN
Drosophila IHRTEGQFHVTTGEEEDCGN R------SSRQPKQRLGKLAA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Functional analysis of a human homolog of the Drosophila actin binding protein anillin suggests a role in cytokinesis.
Oegema K.; Savoian M.S.; Mitchison T.J.; Field C.M.;
J. Cell Biol. 150:539-552(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT LYS-185; FUNCTION; INTERACTION WITH ACTIN; SUBCELLULAR LOCATION;
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Beausoleil S.A.; Villen J.; Gerber S.A.; Rush J.; Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006)
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182; THR-194 AND THR-401; VARIANT [LARGE SCALE ANALYSIS] LYS-185; IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.