Sequence information
Variant position: 251 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 437 The length of the canonical sequence.
Location on the sequence:
TTSNTEMCEVGQVCQETLLL
L DVGLTSTLVGTKGCSTVGAQ
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TTSNTEMCEVGQVCQETLLLL DVGLTSTLVGTKGCSTVGAQ
Mouse TAPGSQVCAPDEICQETLLLI DVGQKSAFLGSKGCSSPGAQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
22 – 408
CD177 antigen
Alternative sequence
146 – 437
Missing. In isoform 3.
Alternative sequence
249 – 437
Missing. In isoform 2.
Literature citations
Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera.
Temerinac S.; Klippel S.; Strunck E.; Roeder S.; Luebbert M.; Lange W.; Azemar M.; Meinhardt G.; Schaefer H.-E.; Pahl H.L.;
Blood 95:2569-2576(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT ILE-251; TISSUE SPECIFICITY; INDUCTION;
Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immunenneutropenia and transfusion reactions.
Kissel K.; Santoso S.; Hofmann C.; Stroncek D.; Bux J.;
Eur. J. Immunol. 31:1301-1309(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); PROTEIN SEQUENCE OF 35-45; 167-175 AND 386-393; VARIANTS PRO-3; PHE-119; ILE-251; GLN-323 AND SER-379; MASS SPECTROMETRY; GLYCOSYLATION;
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Clark H.F.; Gurney A.L.; Abaya E.; Baker K.; Baldwin D.T.; Brush J.; Chen J.; Chow B.; Chui C.; Crowley C.; Currell B.; Deuel B.; Dowd P.; Eaton D.; Foster J.S.; Grimaldi C.; Gu Q.; Hass P.E.; Heldens S.; Huang A.; Kim H.S.; Klimowski L.; Jin Y.; Johnson S.; Lee J.; Lewis L.; Liao D.; Mark M.R.; Robbie E.; Sanchez C.; Schoenfeld J.; Seshagiri S.; Simmons L.; Singh J.; Smith V.; Stinson J.; Vagts A.; Vandlen R.L.; Watanabe C.; Wieand D.; Woods K.; Xie M.-H.; Yansura D.G.; Yi S.; Yu G.; Yuan J.; Zhang M.; Zhang Z.; Goddard A.D.; Wood W.I.; Godowski P.J.; Gray A.M.;
Genome Res. 13:2265-2270(2003)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT ILE-251;
Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
Kalnine N.; Chen X.; Rolfs A.; Halleck A.; Hines L.; Eisenstein S.; Koundinya M.; Raphael J.; Moreira D.; Kelley T.; LaBaer J.; Lin Y.; Phelan M.; Farmer A.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT ILE-251;
Heterogeneity of human neutrophil CD177 expression results from CD177P1 pseudogene conversion.
Wu Z.; Liang R.; Ohnesorg T.; Cho V.; Lam W.; Abhayaratna W.P.; Gatenby P.A.; Perera C.; Zhang Y.; Whittle B.; Sinclair A.; Goodnow C.C.; Field M.; Andrews T.D.; Cook M.C.;
PLoS Genet. 12:E1006067-E1006067(2016)
Cited for: VARIANTS PRO-3; LEU-31; ILE-251; ALA-261; THR-348 AND ARG-431; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; POLYMORPHISM;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.