Variant position: 348 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 437 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human CVQPLGTCSSGSPRMTCPRG ATHCYDGYIHLSGGGLSTKMS
Mouse CVELFGSCKS-TDSVTCPRG ATHCYKGDIALQGGGLTTRVS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
22 – 408 CD177 antigen
325 – 377 UPAR/Ly6 2
146 – 437 Missing. In isoform 3.
249 – 437 Missing. In isoform 2.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANTS PRO-3 AND THR-348;
Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP-neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms.
Wolff J.; Brendel C.; Fink L.; Bohle R.M.; Kissel K.; Bux J.;
Cited for: VARIANT THR-348; POLYMORPHISM;
Heterogeneity of human neutrophil CD177 expression results from CD177P1 pseudogene conversion.
Wu Z.; Liang R.; Ohnesorg T.; Cho V.; Lam W.; Abhayaratna W.P.; Gatenby P.A.; Perera C.; Zhang Y.; Whittle B.; Sinclair A.; Goodnow C.C.; Field M.; Andrews T.D.; Cook M.C.;
PLoS Genet. 12:E1006067-E1006067(2016)
Cited for: VARIANTS PRO-3; LEU-31; ILE-251; ALA-261; THR-348 AND ARG-431; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; POLYMORPHISM;
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