Variant position: 67 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 365 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SNEKKAKKVRFYRNGDRYF-K GIVYAVSSDRFRSFDALLADL
Mouse SNEKKAKKVRFYRNGDRYF-K GIVYAVSSDRFRSFDALLAD
Rat SNEKKAKKVRFYRNGDRYF-K GIVYAVSSDRFRSFDALLAD
Slime mold QTDKSARVI-LFRNGDRYHVE GVHCLVHSSKFKTFDQLKLE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 365 Neuronal migration protein doublecortin
53 – 139 Doublecortin 1
47 – 47 Phosphoserine; by MARK1 and PKA
70 – 70 Phosphotyrosine; by ABL
74 – 74 Phosphoserine; by PKC
Subcortical band heterotopia (SBH) in males: clinical, imaging and genetic findings in comparison with females.
D'Agostino M.D.; Bernasconi A.; Das S.; Bastos A.; Valerio R.M.; Palmini A.; Costa da Costa J.; Scheffer I.E.; Berkovic S.; Guerrini R.; Dravet C.; Ono J.; Gigli G.; Federico A.; Booth F.; Bernardi B.; Volpi L.; Tassinari C.A.; Guggenheim M.A.; Ledbetter D.H.; Gleeson J.G.; Lopes-Cendes I.; Vossler D.G.; Malaspina E.; Franzoni E.; Sartori R.J.; Mitchell M.H.; Mercho S.; Dubeau F.; Andermann F.; Dobyns W.B.; Andermann E.;
Cited for: VARIANTS SBHX GLU-67 AND CYS-178;
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