Variant position: 181 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 242 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VPIIENTPEEKDLKDRMAHA MNEYPDSCAVLVRRHGVYVWG
Mouse VPIIENTPEEKDLKERMAHA MNEYPDSCAVLVRRHGVYVWG
Bovine VPIIENTPEEKDLKERMARA VNDYPDSCAVLVRRHGVYVWG
Chicken VPIIENTPEEKDLKERMAKA MEEYPDSCAVLVRRHGVYVWG
Xenopus laevis VPIVENTPEEKDLKERMARA MTEYPDTCAVLVRRHGVYVWG
Xenopus tropicalis VPIVENTPEEKDLKERMARA MTEYPDTCAVLVRRHGVYVWG
Zebrafish VPIIENTPEEKDLKERMARA MDMYPDSCAVLVRRHGVYVWG
Caenorhabditis elegans IPIIDNMPSESQLLEPIRGV LENYPQAIAVLVRNHGLFVWG
Drosophila VPIIENTPFERDLADSMYAA MMEYPGCSAILVRRHGVYVWG
Slime mold IPIIENTPHERDLKERMHKA MEKYPNANAVLVRRHGVYVWG
Baker's yeast IPIIENMAHEDELIDDLHKT FKDYPDTCAVIVRRHGIFVWG
Fission yeast IPFINNTAHESDLHDSLQEA INLYPDTCAVIVRDHGIYCWG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 242 Methylthioribulose-1-phosphate dehydratase
195 – 195 Zinc; via tele nitrogen
195 – 195 H -> A. Impaired ability of cells to grow in media where methionine is replaced by 5-methylthioadenosine; when associated with 87-A--A-89.
170 – 183
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANTS TRP-7; ARG-23; TYR-76 AND VAL-181;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.