UniProtKB/Swiss-Prot Q9UHK0: Variant p.Ser36Arg

FMR1-interacting protein NUFIP1
Gene: NUFIP1
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Variant information Variant position:

36 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant:

LB/B The variants are classified into three categories: LP/P, LB/B and US.

LP/P: likely pathogenic or pathogenic.
LB/B: likely benign or benign.
US: uncertain significance

Residue change:

From Serine (S) to Arginine (R) at position 36 (S36R, p.Ser36Arg). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties:

Change from small size and polar (S) to large size and basic (R) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score:

-1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page
Other resources:

Links to websites of interest for the variant.

Variant rs1140993 [ dbSNP | Ensembl ]

Sequence information Variant position:

36 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length:

495 The length of the canonical sequence.
Location on the sequence:

ASPELTPTLGPLSDTAPPRD S WMFWAMLPPPPPPLTSSLPA The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         ASPELTPTLGPLSDTAPPRDSWMFWAMLPPPPPPLTSSLPA

Mouse                         SAPDLTPAPGTPSEAAPPRDNWVYWAMLPPPPPPLSS--PV

Rat                           SAPELTPAPGTPSEAAPPQDNWVYWAMLPPPPPPLSS--PV

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	1 – 495	FMR1-interacting protein NUFIP1
Region	1 – 108	Disordered

Literature citations
A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein.
Bardoni B.; Schenck A.; Mandel J.-L.;
Hum. Mol. Genet. 8:2557-2566(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT ARG-36; FUNCTION; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; INTERACTION WITH FMR1;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.