Variant position: 416 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1008 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human YLLEDVIEKIRYVPEQKEHR SQFKRGFMQGHVNRQEKEEKE
Mouse YLLEDIIEKIRYVPDQKEHR SQFKRGFMQGHVNRQEKEEKE
Rat YLLEDIIEKIRYFPEQKEHR SQFKRGFMQGHVNRQEKEEKE
Bovine YLLEDIIEKIRYVPEQKEHR SQFKKGFMQGHVNRQEKEEKE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1008 ATP-dependent DNA/RNA helicase DHX36
387 – 628 RecA-like domain 2
Molecular cloning and characterization of human DDX36 and mouse Ddx36 genes, new members of the DEAD/H box superfamily.
Fu J.-J.; Li L.-Y.; Lu G.-X.;
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:655-661(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; VARIANT CYS-416;
Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU.
Tran H.; Schilling M.; Wirbelauer C.; Hess D.; Nagamine Y.;
Mol. Cell 13:101-111(2004)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); FUNCTION; AU-RICH RNA-BINDING; SUBCELLULAR LOCATION; ACTIVITY REGULATION; ALTERNATIVE SPLICING; TISSUE SPECIFICITY; INTERACTION WITH ELAVL1; ILF3; PARN; EXOSC3 AND EXOSC10; MUTAGENESIS OF GLU-335; VARIANT CYS-416; NUCLEAR LOCALIZATION SIGNAL; IDENTIFICATION BY MASS SPECTROMETRY;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3); VARIANTS CYS-416 AND ASN-583;
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