Sequence information
Variant position: 258 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 299 The length of the canonical sequence.
Location on the sequence:
WRTAQTILEKEAEDVIWEDS
A SENQEGLRKITSYFLNEGSQ
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WRTAQTILE---KE--AEDVIWEDSA -SENQEGLRKITSYFLNEGSQ-
Mouse WSTAQAILE---KE--AEDVIWEDSE AEEDPERPGKITSYF
Rat WSTAQAILE---KE--AESVTWEDSA AEEDPEGPGRITSYF
Bovine WRTAQSILE---SE--AEDVKWEDSE -TGDPKGPGKIKSYF
Caenorhabditis elegans WKTASTIVE---KR--CVPGSWEDDE -EEGKSQSKRMTSWM
Drosophila WSTAENALA---DK--AYDMEFDEPD SEKPKYAGTKLTKFF
Slime mold WKTTETAMR---GA--CFGVDWVLEN --------DKLKQHF
Baker's yeast WQTCQTLLDDASKN--SIPIKWEEQY MDSRKNAAQKTKQLQ
Fission yeast WKTAKDLLELPSKSQSSIEIDWHEDD --------DTPTLNF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 299
Ribonuclease H2 subunit A
Modified residue
257 – 257
Phosphoserine
Modified residue
277 – 277
Phosphoserine
Mutagenesis
240 – 240
T -> A. Strongly reduced enzyme activity.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.