Variant position: 258 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 299 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WRTAQTILE---KE--AEDVIWEDS A-SENQEGLRKITSYFLNEGSQ-
Mouse WSTAQAILE---KE--AEDVIWEDS EAEEDPERPGKITSYF
Rat WSTAQAILE---KE--AESVTWEDS AAEEDPEGPGRITSYF
Bovine WRTAQSILE---SE--AEDVKWEDS E-TGDPKGPGKIKSYF
Caenorhabditis elegans WKTASTIVE---KR--CVPGSWEDD E-EEGKSQSKRMTSWM
Drosophila WSTAENALA---DK--AYDMEFDEP DSEKPKYAGTKLTKFF
Slime mold WKTTETAMR---GA--CFGVDWVLE N--------DKLKQHF
Baker's yeast WQTCQTLLDDASKN--SIPIKWEEQ YMDSRKNAAQKTKQLQ
Fission yeast WKTAKDLLELPSKSQSSIEIDWHED D--------DTPTLNF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 299 Ribonuclease H2 subunit A
257 – 257 Phosphoserine
277 – 277 Phosphoserine
240 – 240 T -> A. Strongly reduced enzyme activity.
No reference for the current variant in UniProtKB/Swiss-Prot.
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