Variant position: 1576 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1588 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ANQADEKYFKCDVCGQLFND RLSLARHQNTHTG
Gorilla ANQADEKYFKCDVCGQLFND RLSLARHQNTHTG
Chimpanzee ANQADEKYFKCDVCGQLFND RLSLARHQNTHTG
Mouse AEQADDKYFKCDVCGQLFND RLSLARHQNSHTG
Bovine --RPDDELFKCDVCGQLFSD RLSLARHQNTHTG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1588 Paternally-expressed gene 3 protein
1564 – 1586 C2H2-type 12
551 – 1588 Missing. In isoform 3.
The human homologue (PEG3) of the mouse paternally expressed gene 3 (Peg3) is maternally imprinted but not mutated in women with familial recurrent hydatidiform molar pregnancies.
Van den Veyver I.B.; Norman B.; Tran C.Q.; Bourjac J.; Slim R.;
J. Soc. Gynecol. Invest. 8:305-313(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); VARIANT LEU-1576;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.