Variant position: 114 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 747 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LYLAALDCAEETNSAVCRDF NIPGFPTVRFFKAFTKNG-SGA
Mouse LNLAVLDCAEETNSAVCREF NIAGFPTVRFFQAFTKNG-SG
Rat LNLAVLDCADETNSAVCREF NIAGFPTVRFFKAFSKNG-TG
Chicken VMIAALDCADEANQQVCADF GITGFPTLKFFRAFSKKAEDG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
30 – 747 Sulfhydryl oxidase 1
36 – 156 Thioredoxin
130 – 130 N-linked (GlcNAc...) (complex) asparagine
119 – 119 P -> ST. Loss of catalytic activity. Decreased protein stability and catalytic activity; when associated with A-72.
130 – 130 N -> Q. Loss of glycosylation site.
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.