Sequence information
Variant position: 174 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 886 The length of the canonical sequence.
Location on the sequence:
SYSCSCQVGFISRNSTCEDV
D ECADPRACPEHATCNNTVGN
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SYSCSCQVGFISRNSTCEDVD ECADPRACPEHATCNNTVGN
Mouse SYSCTCQPGFVLNGSICEDED ECVTRDVCPEHATCHNTLGS
Rat SYSCTCQSGFVSNGSTCEDED ECVTRNACPEHATCHNTLGS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
21 – 886
Adhesion G protein-coupled receptor E1
Topological domain
21 – 599
Extracellular
Domain
172 – 220
EGF-like 4; calcium-binding
Glycosylation
167 – 167
N-linked (GlcNAc...) asparagine
Glycosylation
189 – 189
N-linked (GlcNAc...) asparagine
Glycosylation
194 – 194
N-linked (GlcNAc...) asparagine
Alternative sequence
132 – 220
Missing. In isoform 5.
Alternative sequence
140 – 316
Missing. In isoform 4.
Literature citations
EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments.
Baud V.; Chissoe S.L.; Viegas-Pequignot E.; Diriong S.; N'Guyen V.C.; Roe B.A.; Lipinski M.;
Genomics 26:334-344(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS THR-57; ARG-140; ASN-174; SER-254; VAL-298; MET-389; VAL-424; GLN-496; VAL-539 AND THR-663;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.