Sequence information
Variant position: 505 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1380 The length of the canonical sequence.
Location on the sequence:
ILSGTSSSYQPIQPKDFHHH
H FPDMEIFLRRFANEYPNITR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ILSGTSSSYQPIQPKDFHHHH FPDMEIFLRRFANEYPNITR
Mouse IPPGTPSSHQPIQPKDFHHHH FPDMEIFLRRFANEYPNITR
Rat IPPGTPSSHQPIQPKDFHHHH FPDMEIFLRRFANEYPNITR
Drosophila KLKKQFNGF--LTPTKYEHHN FTAMESYLRAISSSYPSLTR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
32 – 1380
Carboxypeptidase D
Topological domain
32 – 1299
Extracellular
Region
494 – 897
Carboxypeptidase-like 2
Glycosylation
522 – 522
N-linked (GlcNAc...) asparagine
Literature citations
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANTS GLU-36; GLY-454 AND ASN-505;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.