Sequence information
Variant position: 93 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 875 The length of the canonical sequence.
Location on the sequence:
RGHTESCSCPLQQSPRADNS
A PGTPTRKISASEFDRPLRPI
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RGHTESCSCPLQQSPRADNSA PGTPTRKISASEFDRPLRPI
RGHAESCSCSSQQSSRADSSA PGTPTRKISASEFDRPLRPI
Mouse RAHTESCSCSLQQSPHADNTT PGAPARKISASEFDRPLRPI
Rat RAHTESCSCSLPQSPHADNTT PGAPARKISASEFDRPLRPI
Bovine KGHTESCSCPLQPSPRAESSV PGTPTRKISASEFDRPLRPI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 875
cGMP-specific 3',5'-cyclic phosphodiesterase
Region
78 – 102
Disordered
Compositional bias
78 – 99
Polar residues
Modified residue
102 – 102
Phosphoserine
Literature citations
Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase.
Loughney K.; Hill T.R.; Florio V.A.; Uher L.; Rosman G.J.; Wolda S.L.; Jones B.A.; Howard M.L.; McAllister-Lucas L.M.; Sonnenburg W.K.; Francis S.H.; Corbin J.D.; Beavo J.A.; Ferguson K.;
Gene 216:139-147(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PDE5A1 AND PDE5A2); FUNCTION; CATALYTIC ACTIVITY; VARIANT VAL-93;
Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene.
Yanaka N.; Kotera J.; Ohtsuka A.; Akatsuka H.; Imai Y.; Michibata H.; Fujishige K.; Kawai E.; Takebayashi S.; Okumura K.; Omori K.;
Eur. J. Biochem. 255:391-399(1998)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM PDE5A1); VARIANT VAL-93;
Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase.
Stacey P.; Rulten S.; Dapling A.; Phillips S.C.;
Biochem. Biophys. Res. Commun. 247:249-254(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE5A1); VARIANT VAL-93;
Molecular cloning and characterization of human cGMP-specific phosphodiesterase 5A2 cDNA.
Kotera J.; Imai Y.; Omori K.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE5A2); VARIANT VAL-93;
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T.; Suzuki Y.; Nishikawa T.; Otsuki T.; Sugiyama T.; Irie R.; Wakamatsu A.; Hayashi K.; Sato H.; Nagai K.; Kimura K.; Makita H.; Sekine M.; Obayashi M.; Nishi T.; Shibahara T.; Tanaka T.; Ishii S.; Yamamoto J.; Saito K.; Kawai Y.; Isono Y.; Nakamura Y.; Nagahari K.; Murakami K.; Yasuda T.; Iwayanagi T.; Wagatsuma M.; Shiratori A.; Sudo H.; Hosoiri T.; Kaku Y.; Kodaira H.; Kondo H.; Sugawara M.; Takahashi M.; Kanda K.; Yokoi T.; Furuya T.; Kikkawa E.; Omura Y.; Abe K.; Kamihara K.; Katsuta N.; Sato K.; Tanikawa M.; Yamazaki M.; Ninomiya K.; Ishibashi T.; Yamashita H.; Murakawa K.; Fujimori K.; Tanai H.; Kimata M.; Watanabe M.; Hiraoka S.; Chiba Y.; Ishida S.; Ono Y.; Takiguchi S.; Watanabe S.; Yosida M.; Hotuta T.; Kusano J.; Kanehori K.; Takahashi-Fujii A.; Hara H.; Tanase T.-O.; Nomura Y.; Togiya S.; Komai F.; Hara R.; Takeuchi K.; Arita M.; Imose N.; Musashino K.; Yuuki H.; Oshima A.; Sasaki N.; Aotsuka S.; Yoshikawa Y.; Matsunawa H.; Ichihara T.; Shiohata N.; Sano S.; Moriya S.; Momiyama H.; Satoh N.; Takami S.; Terashima Y.; Suzuki O.; Nakagawa S.; Senoh A.; Mizoguchi H.; Goto Y.; Shimizu F.; Wakebe H.; Hishigaki H.; Watanabe T.; Sugiyama A.; Takemoto M.; Kawakami B.; Yamazaki M.; Watanabe K.; Kumagai A.; Itakura S.; Fukuzumi Y.; Fujimori Y.; Komiyama M.; Tashiro H.; Tanigami A.; Fujiwara T.; Ono T.; Yamada K.; Fujii Y.; Ozaki K.; Hirao M.; Ohmori Y.; Kawabata A.; Hikiji T.; Kobatake N.; Inagaki H.; Ikema Y.; Okamoto S.; Okitani R.; Kawakami T.; Noguchi S.; Itoh T.; Shigeta K.; Senba T.; Matsumura K.; Nakajima Y.; Mizuno T.; Morinaga M.; Sasaki M.; Togashi T.; Oyama M.; Hata H.; Watanabe M.; Komatsu T.; Mizushima-Sugano J.; Satoh T.; Shirai Y.; Takahashi Y.; Nakagawa K.; Okumura K.; Nagase T.; Nomura N.; Kikuchi H.; Masuho Y.; Yamashita R.; Nakai K.; Yada T.; Nakamura Y.; Ohara O.; Isogai T.; Sugano S.;
Nat. Genet. 36:40-45(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PDE5A1); VARIANT VAL-93;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.