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UniProtKB/Swiss-Prot Q14686: Variant p.Asn955Ser

Nuclear receptor coactivator 6
Gene: NCOA6
Variant information

Variant position:  955
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Asparagine (N) to Serine (S) at position 955 (N955S, p.Asn955Ser).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and polar (N) to small size and polar (S)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  955
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  2063
The length of the canonical sequence.

Location on the sequence:   TRPAGLEEADQPPLPGEQGI  N LDNSGPKLPEFSNRPPGYPS
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         TRPAGLEEADQPPLPGEQGINLDNSGPKLPEFSNRPPGYPS

Mouse                         NRPTGLEEVDQQSLPGEQGINLDTTGPKLPDFSNRPPGYPT

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 2063 Nuclear receptor coactivator 6
Region 1 – 1310 NCOA1-binding region
Region 1 – 1057 CREBBP-binding region
Compositional bias 227 – 1041 Gln-rich


Literature citations

A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.
Lee S.-K.; Anzick S.L.; Choi J.-E.; Bubendorf L.; Guan X.-Y.; Jung Y.-K.; Kallioniemi O.-P.; Kononen J.; Trent J.M.; Azorsa D.; Jhun B.-H.; Cheong J.H.; Lee Y.C.; Meltzer P.S.; Lee J.W.;
J. Biol. Chem. 274:34283-34293(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; INTERACTION WITH CREBBP; NCOA1; GTF2A; TBP; RXRA; ESR1; RARA AND THRA; VARIANT SER-955;

A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP.
Mahajan M.A.; Samuels H.H.;
Mol. Cell. Biol. 20:5048-5063(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; HOMODIMERIZATION; INTERACTION WITH CREBBP; RXRA; ESR1; NR3C1; RARA; VDR AND THRA; VARIANT SER-955;

Cloning and characterization of RAP250, a nuclear receptor coactivator.
Caira F.; Antonson P.; Pelto-Huikko M.; Treuter E.; Gustafsson J.-A.;
J. Biol. Chem. 275:5308-5317(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; INTERACTION WITH PPARA; PPARG; ESR1; ESR2 AND THR; VARIANT SER-955;

Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.
Ko L.; Cardona G.R.; Chin W.W.;
Proc. Natl. Acad. Sci. U.S.A. 97:6212-6217(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; PHOSPHORYLATION BY PRKDC; INTERACTION WITH THR; RAR; EP300 AND CRSP3; VARIANT SER-955;

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.
Nagase T.; Seki N.; Ishikawa K.; Tanaka A.; Nomura N.;
DNA Res. 3:17-24(1996)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT SER-955;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.