Variant position: 955 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2063 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TRPAGLEEADQPPLPGEQGI NLDNSGPKLPEFSNRPPGYPS
Mouse NRPTGLEEVDQQSLPGEQGI NLDTTGPKLPDFSNRPPGYPT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 2063 Nuclear receptor coactivator 6
1 – 1310 NCOA1-binding region
1 – 1057 CREBBP-binding region
227 – 1041 Gln-rich
A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.
Lee S.-K.; Anzick S.L.; Choi J.-E.; Bubendorf L.; Guan X.-Y.; Jung Y.-K.; Kallioniemi O.-P.; Kononen J.; Trent J.M.; Azorsa D.; Jhun B.-H.; Cheong J.H.; Lee Y.C.; Meltzer P.S.; Lee J.W.;
J. Biol. Chem. 274:34283-34293(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; INTERACTION WITH CREBBP; NCOA1; GTF2A; TBP; RXRA; ESR1; RARA AND THRA; VARIANT SER-955;
A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP.
Mahajan M.A.; Samuels H.H.;
Mol. Cell. Biol. 20:5048-5063(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; HOMODIMERIZATION; INTERACTION WITH CREBBP; RXRA; ESR1; NR3C1; RARA; VDR AND THRA; VARIANT SER-955;
Cloning and characterization of RAP250, a nuclear receptor coactivator.
Caira F.; Antonson P.; Pelto-Huikko M.; Treuter E.; Gustafsson J.-A.;
J. Biol. Chem. 275:5308-5317(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; INTERACTION WITH PPARA; PPARG; ESR1; ESR2 AND THR; VARIANT SER-955;
Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.
Ko L.; Cardona G.R.; Chin W.W.;
Proc. Natl. Acad. Sci. U.S.A. 97:6212-6217(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; PHOSPHORYLATION BY PRKDC; INTERACTION WITH THR; RAR; EP300 AND CRSP3; VARIANT SER-955;
Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.
Nagase T.; Seki N.; Ishikawa K.; Tanaka A.; Nomura N.;
DNA Res. 3:17-24(1996)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT SER-955;
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