Variant position: 179 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 503 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LAHTHAGLQAPGPLPAPAGD KGDLLLQAVQQSCLADHLLTA
Mouse LARENAGLQTPSPLLSS--D AGDLLLQVLQYS----HILES
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 503 Interferon regulatory factor 7
165 – 503 Missing. In isoform C.
167 – 167 Q -> A. Complete loss of inactivation of IFN-I production; when associated with R-189.
167 – 167 Q -> A. No effect on cleavage by enterovirus 71.
185 – 185 Q -> A. No effect on cleavage by enterovirus 71.
188 – 188 Q -> A. No effect on cleavage by enterovirus 71.
189 – 189 Q -> A. Complete loss of cleavage by enterovirus 71.
189 – 189 Q -> R. Complete loss of inactivation of IFN-I production; when associated with A-167.
Grossman A.; Nicholl J.; Antonio L.; Luethy R.; Suggs S.; Sutherland G.R.; Mak T.W.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A); VARIANT GLU-179;
Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes.
Au W.-C.; Moore P.A.; LaFleur D.W.; Tombal B.; Pitha P.M.;
J. Biol. Chem. 273:29210-29217(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D); VARIANTS GLU-179 AND ARG-412;
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