Variant position: 100 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 344 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GRPLGKGKFGNVYLAREKKS HFIVALKVLFKSQIEKEGVEH
Mouse GRPLGKGKFGNVYLAREKKS RFIVALKILFKSQIEKEGVEH
Rat GRPLGKGKFGNVYLAREKKS RFIVALKILFKSQIEKEGVEH
Pig GRPLGKGKFGNVYLAREKKS HFIVALKVLFKSQIEKEGVEH
Bovine GRPLGKGKFGNVYLAREKKS HFIVALKVLFKSQIEKEGVEH
Xenopus tropicalis GRPLGKGKFGNVYLARDKQN KFIMALKVLFKSQLEKEGVEH
Zebrafish GRPLGKGKFGNVYLARERKL KVVIALKVLFKSQMVKEGVEH
Drosophila GAHLGRGKFGRVYLARERHS HYLVAMKVMFKEELRKGCVQR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 344 Aurora kinase B
77 – 327 Protein kinase
106 – 106 ATP
86 – 134 GKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH -> ALLCLWPEASSVSSPSH. In isoform 2.
106 – 106 K -> R. Leads to loss of kinase activity and severely impairs mitotic progression.
No reference for the current variant in UniProtKB/Swiss-Prot.
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