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UniProtKB/Swiss-Prot Q96GD4: Variant p.Met298Thr

Aurora kinase B
Gene: AURKB
Variant information

Variant position:  298
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Methionine (M) to Threonine (T) at position 298 (M298T, p.Met298Thr).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and hydrophobic (M) to medium size and polar (T)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  298
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  344
The length of the canonical sequence.

Location on the sequence:   HNETYRRIVKVDLKFPASVP  M GAQDLISKLLRHNPSERLPL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         HNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPL

Mouse                         HSETYRRIVKVDLKFPSSVPSGAQDLISKLLKHNPWQRLPL

Rat                           HSETYRRIVKVDLKFPSSMPLGAKDLISKLLKHNPSQRLPL

Pig                           HNETYRRIGKVDLKFPPSVPAGAQDLISKLLKHNPSDRLPL

Bovine                        HNETYRRIVKVDLKFPPSVPLGAQDFIYKLLKHNPSERLPL

Xenopus tropicalis            HTETHRRIVNVDLKFPPFLSDGSKDLISKLLRYHPPQRLPL

Zebrafish                     HAETYKRITKVDLQFPKLVSEGARDLISKLLRHSPSMRLPL

Drosophila                    TESTYSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRITL

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 344 Aurora kinase B
Domain 77 – 327 Protein kinase
Alternative sequence 142 – 344 Missing. In isoform 3.
Helix 298 – 307


Literature citations

cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.
Shindo M.; Nakano H.; Kuroyanagi H.; Shirasawa T.; Mihara M.; Gilbert D.J.; Jenkins N.A.; Copeland N.G.; Yagita H.; Okumura K.;
Biochem. Biophys. Res. Commun. 244:285-292(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT THR-298;

Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells.
Tatsuka M.; Katayama H.; Ota T.; Tanaka T.; Odashima S.; Suzuki F.; Terada Y.;
Cancer Res. 58:4811-4816(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; VARIANT THR-298;

Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1.
Kimura M.; Matsuda Y.; Yoshioka T.; Sumi N.; Okano Y.;
Cytogenet. Cell Genet. 82:147-152(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; VARIANT THR-298;

In silico cloning of a new protein kinase, Aik2, related to Drosophila aurora using the new tool: EST Blast.
Prigent C.; Gill R.; Trower M.; Sanseau P.;
In Silico Biol. 1:123-128(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT THR-298;

Cloning of a novel human gene homologous to mouse STK-1.
Zhang Q.; Yu L.; Bi A.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT THR-298;

Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
Kalnine N.; Chen X.; Rolfs A.; Halleck A.; Hines L.; Eisenstein S.; Koundinya M.; Raphael J.; Moreira D.; Kelley T.; LaBaer J.; Lin Y.; Phelan M.; Farmer A.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT THR-298;

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5); VARIANT THR-298;

Aurora kinases A and B and familial breast cancer risk.
Tchatchou S.; Wirtenberger M.; Hemminki K.; Sutter C.; Meindl A.; Wappenschmidt B.; Kiechle M.; Bugert P.; Schmutzler R.K.; Bartram C.R.; Burwinkel B.;
Cancer Lett. 247:266-272(2007)
Cited for: VARIANT THR-298;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.