Variant position: 113 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 199 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EELNKLLLQLYLDNRKEIRT ILSELAPSLPSYHNLEWRLDV
Mouse EELNKLLLQLYLDNRKEIRT ILNELAPRLPSYHSLEWRLDV
Slime mold DEVIEILRESYFDNRKDIRN TLQEFYPHLDHYQNLEWRLDT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 199 COMM domain-containing protein 2
COMMD proteins, a novel family of structural and functional homologs of MURR1.
Burstein E.; Hoberg J.E.; Wilkinson A.S.; Rumble J.M.; Csomos R.A.; Komarck C.M.; Maine G.N.; Wilkinson J.C.; Mayo M.W.; Duckett C.S.;
J. Biol. Chem. 280:22222-22232(2005)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; INTERACTION WITH COMMD1; RELA; RELB; NFKB1 AND NFKB2; TISSUE SPECIFICITY; VARIANT LEU-113;
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
Zhang Q.-H.; Ye M.; Wu X.-Y.; Ren S.-X.; Zhao M.; Zhao C.-J.; Fu G.; Shen Y.; Fan H.-Y.; Lu G.; Zhong M.; Xu X.-R.; Han Z.-G.; Zhang J.-W.; Tao J.; Huang Q.-H.; Zhou J.; Hu G.-X.; Gu J.; Chen S.-J.; Chen Z.;
Genome Res. 10:1546-1560(2000)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT LEU-113;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2); VARIANT LEU-113;
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