Variant position: 17 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 117 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MAAAAAAGSGTPRE--EE GPAGEAAASQPQAPTSVP----------GA-R
Mouse MAAAAAAGSGTPRE--EE APGGEAAASQAQAPTSAP-
Bovine -MAAAAPGSGAARE--EE GTGGDAATPQPPAPTSAP-
Drosophila TEEAELAETEEPLEITEE SPDNPEAESTTEQLTEKPV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1 Removed
2 – 117 DNA polymerase epsilon subunit 4
1 – 36 Disordered
2 – 2 N-acetylalanine
11 – 11 Phosphothreonine
25 – 25 Phosphoserine
Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.
Li Y.; Pursell Z.F.; Linn S.;
J. Biol. Chem. 275:23247-23252(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; FUNCTION; IDENTIFICATION IN EPSILON DNA POLYMERASE COMPLEX; VARIANT VAL-17;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT VAL-17;
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S.; Ballif B.A.; Smogorzewska A.; McDonald E.R. III; Hurov K.E.; Luo J.; Bakalarski C.E.; Zhao Z.; Solimini N.; Lerenthal Y.; Shiloh Y.; Gygi S.P.; Elledge S.J.;
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; VARIANT [LARGE SCALE ANALYSIS] VAL-17; IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.