Sequence information
Variant position: 124 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 136 The length of the canonical sequence.
Location on the sequence:
KKTKAAAAAAAAAPAAAATA
P TTAATTAATAAQ
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KKTKAAAAAAAAAPAAAATAP TTAATTAATAAQ
KKSKPAQ-------------- ------------
Mouse KKSKPAQ-------------- ------------
Bovine KKSKAAQ-------------- ------------
Caenorhabditis elegans KKKTGATKA------------ ------------
Slime mold TTTPSSSTTAKTAAKKTKV-- ------------
Baker's yeast NGTISKTGKKNKVAKKN---- ------------
Fission yeast KNKKKTTSSGHT--------- ------------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 136
Signal recognition particle 14 kDa protein
Compositional bias
108 – 136
Ala/Thr-rich
Literature citations
The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs.
Bovia F.; Fornallaz M.; Leffers H.; Strub K.;
Mol. Biol. Cell 6:471-484(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT ALA-124;
A novel gene encoding signal recognition particle 14kD is upregulated in the acute morphine dependent SH-SY5Y cells.
Wang H.; Gao X.; Huang Y.; Han J.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT ALA-124;
Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
Goshima N.; Kawamura Y.; Fukumoto A.; Miura A.; Honma R.; Satoh R.; Wakamatsu A.; Yamamoto J.; Kimura K.; Nishikawa T.; Andoh T.; Iida Y.; Ishikawa K.; Ito E.; Kagawa N.; Kaminaga C.; Kanehori K.; Kawakami B.; Kenmochi K.; Kimura R.; Kobayashi M.; Kuroita T.; Kuwayama H.; Maruyama Y.; Matsuo K.; Minami K.; Mitsubori M.; Mori M.; Morishita R.; Murase A.; Nishikawa A.; Nishikawa S.; Okamoto T.; Sakagami N.; Sakamoto Y.; Sasaki Y.; Seki T.; Sono S.; Sugiyama A.; Sumiya T.; Takayama T.; Takayama Y.; Takeda H.; Togashi T.; Yahata K.; Yamada H.; Yanagisawa Y.; Endo Y.; Imamoto F.; Kisu Y.; Tanaka S.; Isogai T.; Imai J.; Watanabe S.; Nomura N.;
Nat. Methods 5:1011-1017(2008)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT ALA-124;
Submission
Mural R.J.; Istrail S.; Sutton G.G.; Florea L.; Halpern A.L.; Mobarry C.M.; Lippert R.; Walenz B.; Shatkay H.; Dew I.; Miller J.R.; Flanigan M.J.; Edwards N.J.; Bolanos R.; Fasulo D.; Halldorsson B.V.; Hannenhalli S.; Turner R.; Yooseph S.; Lu F.; Nusskern D.R.; Shue B.C.; Zheng X.H.; Zhong F.; Delcher A.L.; Huson D.H.; Kravitz S.A.; Mouchard L.; Reinert K.; Remington K.A.; Clark A.G.; Waterman M.S.; Eichler E.E.; Adams M.D.; Hunkapiller M.W.; Myers E.W.; Venter J.C.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]; VARIANT ALA-124;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT ALA-124;
Submission
Bienvenut W.V.; Boldt K.; von Kriegsheim A.F.; Murray L.; Brunton V.G.; Frame M.C.; Calvo F.; Kolch W.;
Cited for: PROTEIN SEQUENCE OF 2-15; 22-31; 79-88 AND 108-136; VARIANT ALA-124; CLEAVAGE OF INITIATOR METHIONINE; IDENTIFICATION BY MASS SPECTROMETRY;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.