Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P17516: Variant p.Gly135Glu

Aldo-keto reductase family 1 member C4
Gene: AKR1C4
Feedback?
Variant information Variant position: help 135
Type of variant: help LB/B
Residue change: help From Glycine (G) to Glutamate (E) at position 135 (G135E, p.Gly135Glu).
Physico-chemical properties: help Change from glycine (G) to medium size and acidic (E)
BLOSUM score: help -2
Polymorphism: help The allele with Cys-145/Val-311 shows a three- to five-fold decrease in catalytic efficiency for xenobiotic and steroidal substrates compared to the Ser-145/Leu-311 allele.
Other resources: help


Sequence information Variant position: help 135
Protein sequence length: help 323
Location on the sequence: help LLHFPMALKPGETPLPKDEN G KVIFDTVDLSATWEVMEKCK
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 323 Aldo-keto reductase family 1 member C4
Binding site 117 – 117



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.