Sequence information
Variant position: 22 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 351 The length of the canonical sequence.
Location on the sequence:
TEMSFLSSEVLVGDLMSPFD
Q SGLGAEESLGLLDDYLEVAK
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TEMSFLSSEVLVGDLMSPFDQ SG--LGAEESLGLLDDYLEVAK
Mouse TEMSFLNSEVLAGDLMSPFDQ SG--LGAEESLGLLDDYLEV
Rat TEMSFLNSEVLAGDLMSPFDQ SG--LGAEESLGLLDDYLEV
Bovine AEMSFLSSEVLGGDFVSPFDQ LG--LGAEESLGLLDDNLEV
Zebrafish SLCVGDAGALLLGPWPLTADP QGPLLDQDEESSVLEGSWSP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 351
Cyclic AMP-dependent transcription factor ATF-4
Literature citations
Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I.
Tsujimoto A.; Nyunoya H.; Morita T.; Sato T.; Shimotohno K.;
J. Virol. 65:1420-1426(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; VARIANT PRO-22;
Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.
Karpinski B.A.; Morle G.D.; Huggenvik J.; Uhler M.D.; Leiden J.M.;
Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT PRO-22;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT PRO-22;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.