Variant position: 22 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 351 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TEMSFLSSEVLVGDLMSPFD QSG--LGAEESLGLLDDYLEVAK
Mouse TEMSFLNSEVLAGDLMSPFD QSG--LGAEESLGLLDDYLEV
Rat TEMSFLNSEVLAGDLMSPFD QSG--LGAEESLGLLDDYLEV
Bovine AEMSFLSSEVLGGDFVSPFD QLG--LGAEESLGLLDDNLEV
Zebrafish SLCVGDAGALLLGPWPLTAD PQGPLLDQDEESSVLEGSWSP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 351 Cyclic AMP-dependent transcription factor ATF-4
Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I.
Tsujimoto A.; Nyunoya H.; Morita T.; Sato T.; Shimotohno K.;
J. Virol. 65:1420-1426(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; VARIANT PRO-22;
Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.
Karpinski B.A.; Morle G.D.; Huggenvik J.; Uhler M.D.; Leiden J.M.;
Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT PRO-22;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT PRO-22;
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