UniProtKB/SwissProt variant VAR

Variant information

Variant position:

22

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:

LB/B

The variants are classified into three categories: LP/P, LB/B and US.

LP/P: likely pathogenic or pathogenic.
LB/B: likely benign or benign.
US: uncertain significance

Residue change:

From Glutamine (Q) to Proline (P) at position 22 (Q22P, p.Gln22Pro).

Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:

Change from medium size and polar (Q) to medium size and hydrophobic (P)

The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:

-1

The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page

Other resources:

Links to websites of interest for the variant.

Variant rs4894 [ dbSNP | Ensembl ]

Sequence information

Variant position:

22

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:

351

The length of the canonical sequence.

Location on the sequence:

TEMSFLSSEVLVGDLMSPFD Q SGLGAEESLGLLDDYLEVAK

The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         TEMSFLSSEVLVGDLMSPFDQSG--LGAEESLGLLDDYLEVAK

Mouse                         TEMSFLNSEVLAGDLMSPFDQSG--LGAEESLGLLDDYLEV

Rat                           TEMSFLNSEVLAGDLMSPFDQSG--LGAEESLGLLDDYLEV

Bovine                        AEMSFLSSEVLGGDFVSPFDQLG--LGAEESLGLLDDNLEV

Zebrafish                     SLCVGDAGALLLGPWPLTADPQGPLLDQDEESSVLEGSWSP

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	1 – 351	Cyclic AMP-dependent transcription factor ATF-4

Literature citations

Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I.
Tsujimoto A.; Nyunoya H.; Morita T.; Sato T.; Shimotohno K.;
J. Virol. 65:1420-1426(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; VARIANT PRO-22;

Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.
Karpinski B.A.; Morle G.D.; Huggenvik J.; Uhler M.D.; Leiden J.M.;
Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT PRO-22;

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT PRO-22;

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P18848: Variant p.Gln22Pro