Sequence information
Variant position: 120 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 385 The length of the canonical sequence.
Location on the sequence:
WVLATQAPRLPSTMLLMNLA
A ADLLLALALPPRIAYHLRGQ
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WVLATQAPRLPSTMLLMNLAA A--DLLLALALPPRIAYHLRGQ
Mouse WVLATRVPRLPSTILLMNLAV A--DLLLALVLPPRLAYHLR
Rat WVLATRVPRLPSTILLMNLAV A--DLLLALVLPPRLVYHLR
Caenorhabditis elegans YTLTRRAVKIMKYDKLRKITN GWENIRSEMSILRRMNHRNV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
48 – 385
Proteinase-activated receptor 4
Transmembrane
109 – 129
Helical; Name=2
Literature citations
Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.
Kahn M.L.; Hammes S.R.; Botka C.; Coughlin S.R.;
J. Biol. Chem. 273:23290-23296(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT THR-120;
A dual thrombin receptor system for platelet activation.
Kahn M.L.; Zheng Y.-W.; Huang W.; Bigornia V.; Zeng D.; Moff S.; Farese R.V. Jr.; Tam C.; Coughlin S.R.;
Nature 394:690-694(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT THR-120;
Cloning and characterization of human protease-activated receptor 4.
Xu W.-F.; Andersen H.; Whitmore T.E.; Presnell S.R.; Yee D.P.; Ching A.; Gilbert T.; Davie E.W.; Foster D.C.;
Proc. Natl. Acad. Sci. U.S.A. 95:6642-6646(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; MUTAGENESIS OF ARG-47 AND ARG-68; VARIANT THR-120;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.