Sequence information
Variant position: 189 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 538 The length of the canonical sequence.
Location on the sequence:
LLKHESVGSQPLQDRVLQVP
V LAHGGCCREDKVVASRLTPE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LLKHESVGSQPLQDRVLQVPV LAHGGCCREDKVVASRLTPE
Mouse LLKQESLGSLPSEVRV----- -THVGHCGEDGVTATRLTSE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 538
Zinc finger protein with KRAB and SCAN domains 3
Modified residue
207 – 207
Phosphothreonine
Cross
171 – 171
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Literature citations
Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
Kalnine N.; Chen X.; Rolfs A.; Halleck A.; Hines L.; Eisenstein S.; Koundinya M.; Raphael J.; Moreira D.; Kelley T.; LaBaer J.; Lin Y.; Phelan M.; Farmer A.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANTS MET-189 AND ALA-200;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.