Variant position: 287 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1543 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SLGW---VLSLLSPFAFTAGMAQ ITHLDNYLSGVIFPDPSGDSY
Slime mold SSSWLRSILFLFSPCAFGEFLYK MGNDQQMMLTTNWSDP--
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1543 ATP-binding cassette sub-family A member 10
68 – 1543 Missing. In isoform 3.
Identifying and characterizing a five-gene cluster of ATP-binding cassette transporters mapping to human chromosome 17q24: a new subgroup within the ABCA subfamily.
Arnould I.; Schriml L.M.; Prades C.; Lachtermacher-Triunfol M.; Schneider T.; Maintoux C.; Lemoine C.; Debono D.; Devaud C.; Naudin L.; Bauche S.; Annat M.; Annilo T.; Allikmets R.; Gold B.; Denefle P.; Rosier M.; Dean M.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; VARIANTS SER-203; VAL-287 AND THR-916;
ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter.
Wenzel J.J.; Kaminski W.E.; Piehler A.; Heimerl S.; Langmann T.; Schmitz G.;
Biochem. Biophys. Res. Commun. 306:1089-1098(2003)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1); VARIANTS SER-203 AND VAL-287; ALTERNATIVE SPLICING (ISOFORMS 2; 3 AND 4); TISSUE SPECIFICITY; INDUCTION; FUNCTION;
The full-ORF clone resource of the German cDNA consortium.
Bechtel S.; Rosenfelder H.; Duda A.; Schmidt C.P.; Ernst U.; Wellenreuther R.; Mehrle A.; Schuster C.; Bahr A.; Bloecker H.; Heubner D.; Hoerlein A.; Michel G.; Wedler H.; Koehrer K.; Ottenwaelder B.; Poustka A.; Wiemann S.; Schupp I.;
BMC Genomics 8:399-399(2007)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5); VARIANTS SER-203 AND VAL-287;
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