UniProtKB/SwissProt variant VAR

FHF complex subunit HOOK-interacting protein 1B
Gene: FHIP1B
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Variant information Variant position:

491
Type of variant:

LB/B
Residue change:

From Threonine (T) to Methionine (M) at position 491 (T491M, p.Thr491Met).
Physico-chemical properties:

Change from medium size and polar (T) to medium size and hydrophobic (M)
BLOSUM score:

-1
Other resources:

Variant rs3750944 [ dbSNP | Ensembl ]

Sequence information Variant position:

491
Protein sequence length:

972
Location on the sequence:

PEHASWARGPGSPSVDSSSV T TVPRPSTPSRLALFLRQQSL
Residue conservation:

Human                         PEHAS-WAR--------------GPGSPSVDSSSVTTVPRPSTPSRLALFLRQQSL

Mouse                         PEHAS-WAR--------------GPGSPSVDSSSVVTVPRP

Rat                           PEHAS-WARGGPSREPGRREDITGPGSPSVDSSSVVTVPRP

Bovine                        PEHAS-WAR--------------GPGSPSVDSSSVVTVHRP

Zebrafish                     DEEPAFWGK--------------VLGSPTSESP---VHPRP

Sequence annotation in neighborhood:

Type	Positions	Description
Chain	1 – 972	FHF complex subunit HOOK-interacting protein 1B
Region	465 – 548	Disordered
Modified residue	510 – 510	Phosphoserine
Alternative sequence	479 – 479	G -> GGPSRETGRREDITG. In isoform 2.

Literature citations
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Nagase T.; Kikuno R.; Hattori A.; Kondo Y.; Okumura K.; Ohara O.;
DNA Res. 7:347-355(2000)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT MET-491; Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T.; Suzuki Y.; Nishikawa T.; Otsuki T.; Sugiyama T.; Irie R.; Wakamatsu A.; Hayashi K.; Sato H.; Nagai K.; Kimura K.; Makita H.; Sekine M.; Obayashi M.; Nishi T.; Shibahara T.; Tanaka T.; Ishii S.; Yamamoto J.; Saito K.; Kawai Y.; Isono Y.; Nakamura Y.; Nagahari K.; Murakami K.; Yasuda T.; Iwayanagi T.; Wagatsuma M.; Shiratori A.; Sudo H.; Hosoiri T.; Kaku Y.; Kodaira H.; Kondo H.; Sugawara M.; Takahashi M.; Kanda K.; Yokoi T.; Furuya T.; Kikkawa E.; Omura Y.; Abe K.; Kamihara K.; Katsuta N.; Sato K.; Tanikawa M.; Yamazaki M.; Ninomiya K.; Ishibashi T.; Yamashita H.; Murakawa K.; Fujimori K.; Tanai H.; Kimata M.; Watanabe M.; Hiraoka S.; Chiba Y.; Ishida S.; Ono Y.; Takiguchi S.; Watanabe S.; Yosida M.; Hotuta T.; Kusano J.; Kanehori K.; Takahashi-Fujii A.; Hara H.; Tanase T.-O.; Nomura Y.; Togiya S.; Komai F.; Hara R.; Takeuchi K.; Arita M.; Imose N.; Musashino K.; Yuuki H.; Oshima A.; Sasaki N.; Aotsuka S.; Yoshikawa Y.; Matsunawa H.; Ichihara T.; Shiohata N.; Sano S.; Moriya S.; Momiyama H.; Satoh N.; Takami S.; Terashima Y.; Suzuki O.; Nakagawa S.; Senoh A.; Mizoguchi H.; Goto Y.; Shimizu F.; Wakebe H.; Hishigaki H.; Watanabe T.; Sugiyama A.; Takemoto M.; Kawakami B.; Yamazaki M.; Watanabe K.; Kumagai A.; Itakura S.; Fukuzumi Y.; Fujimori Y.; Komiyama M.; Tashiro H.; Tanigami A.; Fujiwara T.; Ono T.; Yamada K.; Fujii Y.; Ozaki K.; Hirao M.; Ohmori Y.; Kawabata A.; Hikiji T.; Kobatake N.; Inagaki H.; Ikema Y.; Okamoto S.; Okitani R.; Kawakami T.; Noguchi S.; Itoh T.; Shigeta K.; Senba T.; Matsumura K.; Nakajima Y.; Mizuno T.; Morinaga M.; Sasaki M.; Togashi T.; Oyama M.; Hata H.; Watanabe M.; Komatsu T.; Mizushima-Sugano J.; Satoh T.; Shirai Y.; Takahashi Y.; Nakagawa K.; Okumura K.; Nagase T.; Nomura N.; Kikuchi H.; Masuho Y.; Yamashita R.; Nakai K.; Yada T.; Nakamura Y.; Ohara O.; Isogai T.; Sugano S.;
Nat. Genet. 36:40-45(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3); VARIANT MET-491;

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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q8N612: Variant p.Thr491Met