Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P13647: Variant p.Asp197Glu

Keratin, type II cytoskeletal 5
Gene: KRT5
Feedback?
Variant information Variant position: help 197
Type of variant: help LB/B
Residue change: help From Aspartate (D) to Glutamate (E) at position 197 (D197E, p.Asp197Glu).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and acidic.
BLOSUM score: help 2
Other resources: help


Sequence information Variant position: help 197
Protein sequence length: help 590
Location on the sequence: help NKFASFIDKVRFLEQQNKVL D TKWTLLQEQGTKTVRQNLEP
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 590 Keratin, type II cytoskeletal 5
Domain 168 – 481 IF rod
Region 168 – 203 Coil 1A



Literature citations
Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control.
Lersch R.; Stellmach V.; Stocks X.; Giudice G.; Fuchs E.;
Mol. Cell. Biol. 9:3685-3697(1989)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT GLU-197; Sequence and expression of a type II keratin, K5, in human epidermal cells.
Lersch R.; Fuchs E.;
Mol. Cell. Biol. 8:486-493(1988)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 83-590; VARIANT GLU-197;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.