Variant position: 387 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 590 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ELQQTAGRHGDDLRNTKHEI SEMNRMIQRLRAEIDNVKKQC
Chimpanzee ELQQTAGRHGDDLRNTKHEI SEMNRMIQRLRAEIDNVKKQC
Mouse ELQQTAGRHGDDLRNTKHEI SEMNRMIQRLRSEIDNVKKQC
Rat ELQQTAGRHGDDLRNTKHEI SEMNRMIQRLRSEIDNVKKQC
Bovine ELQQTAGRHGDDLRNTKHEI SEMNRMIQRLRSEIDNVKKQC
Xenopus laevis ELQAAAGRHGDDLRSTKTEI SELNRAMQRLQAEIESVKAQR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
The sequence of the human epidermal 58-kD (#5) type II keratin reveals an absence of 5' upstream sequence conservation between coexpressed epidermal keratins.
Eckert R.L.; Rorke E.A.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS ARG-79 AND THR-387;
Genomic organization and amplification of the human epidermal type II keratin genes K1 and K5.
Whittock N.V.; Eady R.A.J.; McGrath J.A.;
Biochem. Biophys. Res. Commun. 274:149-152(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ARG-79 AND THR-387;
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